Role of proteolysis in development of murine adipose tissue

被引：47

作者：

Christiaens, Valerie ^{[1
]}

Scroyen, Ilse ^{[1
]}

Lijnen, H. Roger ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium

来源：

THROMBOSIS AND HAEMOSTASIS | 2008年 / 99卷 / 02期

关键词：

animal models; fibrinolysis inhibitors; gene knock-out; matrix metalloproteinases; obesity;

D O I：

10.1160/TH07-10-0589

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is a common disorder, and related diseases such as diabetes, atherosclerosis, hypertension, cardiovascular disease and cancer are a major cause of mortality and morbidity in Western-type societies. Development of obesity is associated with extensive modifications in adipose tissue involving adipogenesis, angiogenesis and extracellular matrix proteolysis. The fibrinolytic (plasminogen/plasmin) and matrix metalloproteinase (MMP) systems cooperate in these processes. A nutritionally induced obesity model in transgenic mice has been used extensively to study the role of the fibrinolytic and MMP systems in the development of obesity. These studies support a role of both systems in adipogenesis and obesity, and suggest that modulation of proteolytic activity may affect development of adipose tissue.

引用

页码：290 / 294

页数：5

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