TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase

被引：35

作者：

van Eijk, Marco ^{[1
]}

Scheij, Saskia S. ^{[1
]}

van Roomen, Cindy P. A. A. ^{[1
]}

Speijer, Dave ^{[1
]}

Boot, Rolf G. ^{[1
]}

Aerts, Johannes M. F. G. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, NL-1100 DE Amsterdam, Netherlands

来源：

FEBS LETTERS | 2007年 / 581卷 / 28期

关键词：

human; monocytes/macrophages; neutrophils;

D O I：

10.1016/j.febslet.2007.10.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human chitotriosidase is specifically expressed by phagocytes, has anti-fungal activity towards chitin-containing fungi in vitro and in vivo, and is part of innate immunity. We studied the effect of toll-like receptor (TLR)- and nucleotide-binding oligomerization domain ( NOD)- 2 triggering on chitotriosidase expression and release by phagocytes. We find that TLR, but not NOD2 activation, regulates chitotriosidase release by neutrophils. Furthermore, both TLR and NOD2 activation resulted in diminished induction by monocytes. Lastly, NOD2 activation, but not TLR stimulation, induces chitinase expression in macrophages. We conclude that phagocyte-specific regulation is important for efficient eradication of chitin-containing pathogens. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：5389 / 5395

页数：7

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