The dexamethasone suppression test and DSM-III-R diagnoses in suicide attempters

被引:14
作者
Westrin, Å [1 ]
Frii, K [1 ]
Träskman-Bendz, L [1 ]
机构
[1] Lund Univ, Dept Clin Neurosci, Div Psychiat, S-22185 Lund, Sweden
关键词
personality disorder; depressive disorder; suicide attempts; pituitary-adrenal system; cortisol;
D O I
10.1016/j.eurpsy.2003.07.004
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Previous research on hypothalamic-pituitary adrenal (HPA) axis-activity in suicide attempter research has shown conflicting outcomes. The design of the present study was to test the influence of personality disorders and concominant axis I diagnoses on the dexamethasone suppression diagnostic test by use of multiple regression analyses. The sample consisted of 184 patients with a recent suicide attempt and 42 healthy controls. As expected, the lowest pre- and postdexamethasone cortisol levels were found in patients with personality disorders axis II, cluster B as compared to the other patients. The results remained significant when analysed for covariance with DSM-III-R axis I diagnoses, age or sex. Whether these low cortisol levels are due to previous experience of extreme stressful events or long-lasting burden, or whether they may be a consequence of biogenetic or psychological predisposal of interest, remains to be elucidated. Axis I comorbidity needs to be further examined. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:350 / 355
页数:6
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