Drastic effect of a single base difference between human and Tetrahymena telomere sequences on their structures under molecular crowding conditions

被引：73

作者：

Miyoshi, D

Karimata, H

Sugimoto, N

机构：

[1] Konan Univ, Fac Sci & Engn, FIBER, Higashinada Ku, Kobe, Hyogo 6588501, Japan

[2] Konan Univ, Fac Sci & Engn, Dept Chem, Kobe, Hyogo 6588501, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 24期

关键词：

DNA structures; molecular devices; nanostructures; oligonucleotides; self-assembly;

D O I：

10.1002/anie.200462667

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Making a difference: Tetrahymena telomere sequences form well-ordered G-wires in the presence of cosolutes, whereas human telomere sequences remain as compact G-quadruplexes (see picture). A single base difference in telomere sequences therefore can affect telomere function under cell-like conditions. The G-wire structure may be useful in the design of DNA nanomaterials. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：3740 / 3744

页数：5

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