Changes in the colocalization of glutamate ionotropic receptor subunits in the human epileptic temporal lobe cortex

被引：11

作者：

González-Albo, MC

Gómez-Utrero, E

Sánchez, A

Sola, RG

DeFelipe, J

机构：

[1] CSIC, Inst Cajal, Madrid 28002, Spain

[2] Hosp Princesa, Dept Neurophysiol, Madrid, Spain

[3] Hosp Princesa, Dept Neurosurg, Madrid, Spain

来源：

EXPERIMENTAL BRAIN RESEARCH | 2001年 / 138卷 / 03期

关键词：

epilepsy; AMPA; kainate; NMDA; colocalization;

D O I：

10.1007/s002210100720

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Double-labeling immunocytochemical techniques and con-focal microscopy were used to quantify possible differences in the degree of colocalization of glutamate ionotropic receptor subunits between nonspiking and spiking neocortex removed from temporal lobe epileptic patients. Spiking neocortex was characterized by laminar-specific changes in the number of cells immunoreactive for NMDAR1, GluR2/3 and GluR5/6/7 subunits, as well as the percentage of cells which colocalized various combinations of these receptors, These changes may lead to profound modifications in the functioning of excitatory synaptic circuits in spiking cortex.

引用

页码：398 / 402

页数：5

共 51 条

[1] Origin and propagation of interictal discharges in the acute electrocorticogram - Implications for pathophysiology and surgical treatment of temporal lobe epilepsy [J].