Gestational and smoking effects on peptidase activity in the placenta

被引：10

作者：

Kenagy, J

Liu, F

Soares, MJ

Audus, KL

机构：

[1] Univ Kansas, Dept Pharmaceut Chem, Lawrence, KS 66047 USA

[2] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66160 USA

来源：

PEPTIDES | 1998年 / 19卷 / 10期

关键词：

placenta; trophoblast; angiotensin converting enzyme; leucine aminopeptidase; development; smoking;

D O I：

10.1016/S0196-9781(98)00118-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Angiotensin converting enzyme (ACE) and leucine aminopeptidase (LAP) regulate fetally and maternally generated peptides in the placenta. In this study, ACE-like activity was found to be decreased and LAP-like activity increased with increasing days of gestation in rat placental tissues forming the fetal:maternal interface. Membrane-associated ACE-like and LAP-Like activities in the placenta of smokers were also found to be significantly higher than their respective activities in placenta of nonsmokers. Our collective findings suggest that gestational and environmentally-induced changes in placental peptidase activities may account for variable peptide hormone and/or therapeutic peptide metabolism in the placenta. (C) 1998 Elsevier Science Inc.

引用

页码：1659 / 1666

页数：8

共 30 条

[1]

AUDUS KL, 1998, A BENZON S, V43, P67

[2]

MICROSOMAL AND LYSOSOMAL-ENZYMES OF TRIACYLGLYCEROL METABOLISM IN RAT PLACENTA [J].