Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

被引：815

作者：

Mei, Lin ^{[1
]}

Xiong, Wen-Cheng ^{[1
]}

机构：

[1] Med Coll Georgia, Program Dev Neurobiol, Inst Mol Med & Genet, Dept Neurol, Augusta, GA 30912 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2008年 / 9卷 / 06期

关键词：

D O I：

10.1038/nrn2392

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Schizophrenia is a highly debilitating mental disorder that affects similar to 1% of the general population, yet it continues to be poorly understood. Recent studies have identified variations in several genes that are associated with this disorder in diverse populations, including those that encode neuregulin 1 (NRG1) and its receptor ErbB4. The past few years have witnessed exciting progress in our knowledge of NRG1 and ErbB4 functions and the biological basis of the increased risk for schizophrenia that is potentially conferred by polymorphisms in the two genes. An improved understanding of the mechanisms by which altered function of NRG1 and ErbB4 contributes to schizophrenia might eventually lead to the development of more effective therapeutics.

引用

页码：437 / 452

页数：16

共 214 条

[1]

Adlkofer K, 2000, GLIA, V29, P104, DOI 10.1002/(SICI)1098-1136(20000115)29:2<104::AID-GLIA2>3.0.CO

[2]

2-2

[3] Heregulin‐stimulated acetylcholine receptor gene expression in muscle: requirement for MAP kinase and evidence for a parallel inhibitory pathway independent of electrical activity [J].