Poly(N-vinylpyrrolidone)-modified surfaces repel plasma protein adsorption

被引：23

作者：

Liu, Xiao-li ^{[1
,2
]}

Wu, Zhao-qiang ^{[1
]}

Li, Dan ^{[1
,2
]}

Chen, Hong ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

[2] Wuhan Univ Technol, Sch Mat Sci & Engn, Wuhan 430070, Peoples R China

来源：

CHINESE JOURNAL OF POLYMER SCIENCE | 2012年 / 30卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Poly(N-vinylpyrrolidone); Surface modification; Protein adsorption; ATRP; Biocompatibility; POLY(ETHYLENE GLYCOL); MOLECULAR SIMULATION; CHAIN DENSITY; POLYMERS; VINYLPYRROLIDONE; POLYURETHANE; FIBRINOGEN; ADHESION; FILMS; OXIDE;

D O I：

10.1007/s10118-012-1118-2

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

The present work aimed to study the interaction between plasma proteins and PVP-modified surfaces under more complex protein conditions. In the competitive adsorption of fibrinogen (Fg) and human serum albumin (HSA), the modified surfaces showed preferential adsorption of HSA. In 100% plasma, the amount of Fg adsorbed onto PVP-modified surfaces was as low as 10 ng/cm(2), suggesting the excellent protein resistance properties of the modified surfaces. In addition, immunoblots of proteins eluted from the modified surfaces after plasma contact confirmed that PVP-modified surfaces can repel most plasma proteins, especially proteins that play important roles in the process of blood coagulation.

引用

页码：235 / 241

页数：7

共 29 条

[1]

Protein resistant polyurethane surfaces by chemical grafting of PEO: amino-terminated PEO as grafting reagent [J].