Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restriction

被引：126

作者：

Prolla, TA

Mattson, MP

机构：

[1] Univ Wisconsin, Dept Genet, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Med Genet, Madison, WI 53706 USA

[3] NIA, Neurosci Lab, Gerontol Res Ctr, Baltimore, MD 21224 USA

[4] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

来源：

TRENDS IN NEUROSCIENCES | 2001年 / 24卷 / 11期

关键词：

D O I：

10.1016/S0166-2236(00)01957-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The application of modern molecular and cell biology technologies to studies of the neurobiology of aging provides a window on the molecular substrates of successful brain aging and neurodegenerative disorders. Aging is associated with increased oxidative stress, disturbances in energy metabolism and inflammation-like processes. Dietary restriction (DR) can extends lifespan and might increase the resistance of the nervous system to age-related neurodegenerative disorders. The neuroprotective effect of DR involves a preconditioning response in which the production of neurotrophic factors and protein chaperones is increased resulting in protection against oxyradical production, stabilization of cellular calcium homeostasis, and inhibition of apoptosis. DR might also enhance neurogenesis, synaptic plasticity and self-repair mechanisms.

引用

页码：S21 / S31

页数：11

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