A practical, metal-free synthesis of 1H-indazoles

被引：90

作者：

Counceller, Carla M. ^{[1
]}

Eichman, Chad C. ^{[1
]}

Wray, Brenda C. ^{[1
]}

Stambuli, James P. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Evans Chem Labs, Columbus, OH 43210 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 05期

关键词：

D O I：

10.1021/ol800053f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1H-indazoles is achieved from o-aminobenzoximes by the selective activation of the oxime in the presence of the amino group. The reaction occurs with a variety of substituted o-aminobenzoximes using a slight excess of methanesulfonyl chloride and triethylamine at 0-23 degrees C and is amenable to scale-up, The synthesis of 1H-indazoles under these conditions is extremely mild compared with previous synthetic approaches and affords the desired compounds in good to excellent yields.

引用

页码：1021 / 1023

页数：3

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