Role of extracorporeal photochemotherapy in patients with refractory chronic graft-versus-host disease

被引：51

作者：

Rubegni, P

Cuccia, A

Sbano, P

Cevenini, G

Carcagnì, MR

D'Ascenzo, G

De Aloe, G

Guidi, S

Guglielmetti, P

Marotta, G

Lauria, F

Bosi, A

Fimiani, M

机构：

[1] Univ Siena, Ist Sci Dermatol, Policlin Scotte, Dept Clin Med & Immunol Sci,Sect Dermatol, I-53100 Siena, Italy

[2] Univ Siena, Dept Cardiac Surg & Biomed Technol, I-53100 Siena, Italy

[3] Univ Florence, Dept Haematol, Florence, Italy

[4] Univ Florence, Bone Marrow Transplant Unit, Florence, Italy

[5] Univ Siena, Sect Haematol, I-53100 Siena, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2005年 / 130卷 / 02期

关键词：

graft-versus-host disease; extracorporeal photochemotherapy; ultraviolet; stem cell transplantation; bone marrow;

D O I：

10.1111/j.1365-2141.2005.05586.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent studies suggest that extracorporeal photochemotherapy (ECP) may be beneficial in patients with steroid-refractory chronic graft-versus-host disease (cGvHD). However, it is not yet clear whether certain conditions, such as age, mode of onset of cGvHD etc., influence clinical response and whether certain affected organs are more sensitive to ECP than others. We analysed the main clinical and laboratory parameters related to evolution of the disease in 32 steroid-refractory cGvHD patients, to identify any useful response predictors to ECP. ECP affected the course of the disease positively in 78% (25/32) of our cases.

引用

页码：271 / 275

页数：5

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