Palladium-catalyzed regioselective arylation of imidazo[1,2-a]pyrimidine

被引：119

作者：

Li, WJ ^{[1
]}

Nelson, DP ^{[1
]}

Jensen, MS ^{[1
]}

Hoerrner, RS ^{[1
]}

Javadi, GJ ^{[1
]}

Cai, D ^{[1
]}

Larsen, RD ^{[1
]}

机构：

[1] Merck Res Labs, Proc Res Dept, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 25期

关键词：

D O I：

10.1021/ol035878k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Imidazo[1,2-a]pyrimidine can be arylated at the 3-position with aryl bromides in the presence of base and a catalytic amount of palladium. This provides an efficient one-step synthesis of 3-arylimidazo[1,2-a]pyrimidines from the unsubstituted heterocycle.

引用

页码：4835 / 4837

页数：3

共 15 条

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