Casein kinase I: Another cog in the circadian clockworks

被引:73
作者
Eide, EJ
Virshup, DM
机构
[1] Univ Utah, Huntsman Canc Inst, Ctr Children, Salt Lake City, UT 84112 USA
[2] Univ Utah, Dept Oncol Sci, Salt Lake City, UT 84112 USA
[3] Univ Utah, Dept Pediat, Salt Lake City, UT USA
关键词
casein kinase; circadian rhythm; double-time; phosphorylation;
D O I
10.1081/CBI-100103963
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Multiple components of the circadian central clock are phosphoproteins, and it has become increasingly clear that posttranslational modification is an important regulator of circadian rhythm in diverse organisms, from dinoflagellates to humans. Genetic studies in Drosophila have identified double-time (dbt), a serine/threonine protein kinase that is highly homologous to human casein kinase I epsilon (CKI epsilon), as the first kinase linked to behavioral rhythms. Identification of a missense mutation in CKT epsilon as the tau mutation in the Syrian hamster places CKI epsilon within the core clock machinery in mammals. Most recently, identification of a phosphorylation site mutant of hPER2 in a family with an inherited circadian rhythm abnormality strongly suggests that PER2 is a physiologically relevant substrate of CKI. Phosphorylation may regulate multiple properties of clock proteins, including stability and intracellular localization.
引用
收藏
页码:389 / 398
页数:10
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