Role of integrins in fibrosing liver diseases

被引：83

作者：

Patsenker, Eleonora ^{[1
]}

Stickel, Felix ^{[1
]}

机构：

[1] Univ Bern, Inselspital, Dept Visceral Surg & Med, CH-3010 Bern, Switzerland

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2011年 / 301卷 / 03期

关键词：

extracellular matrix; hepatic stellate cell/myofibroblast; inflammation; antifibrotic therapy; HEPATIC STELLATE CELLS; PRIMARY BILIARY-CIRRHOSIS; GLY-ASP RGD; ADHESION MOLECULES; IMMUNOHISTOCHEMICAL ANALYSIS; PHARMACOLOGICAL INHIBITION; ALPHA(V)BETA(3) INTEGRIN; ANTIFIBROTIC THERAPIES; PRIMARY CULTURE; PORTAL TRACTS;

D O I：

10.1152/ajpgi.00050.2011

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Integrins and other cell adhesion molecules regulate numerous physiological and pathological mechanisms by mediating the interaction between cells and their extracellular environment. Although the significance of integrins in the evolution and progression of certain cancers is well recognized, their involvement in nonmalignant processes, such as organ fibrosis or inflammation, is only beginning to emerge. However, accumulating evidence points to an instrumental role of integrin-mediated signaling in a variety of chronic and acute noncancerous diseases, particularly of the liver.

引用

页码：G425 / G434

页数：10

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