Prognostic value of cytokines in SIRS general medical patients

被引：81

作者：

Rodríguez-Gaspar, M

Santolaria, F ^{[1
]}

Jarque-López, A

González-Reimers, E

Milena, A

de la Vega, MJ

Rodríguez-Rodríguez, E

Gómez-Sirvent, JL

机构：

[1] Univ La Laguna, Hosp Univ Canarias, Med Interna Serv, Tenerife, Spain

[2] Univ La Laguna, Hosp Univ Canarias, Lab Serv, Tenerife, Spain

来源：

CYTOKINE | 2001年 / 15卷 / 04期

关键词：

D O I：

10.1006/cyto.2001.0932

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We studied 174 patients with SIRS criteria, 45 with sepsis, eight with severe sepsis and 13 with septic shock. Serum TNF-alpha, IL-6, IL-8 and IL-10 levels were raised in SIRS patients, even in those cases in which an infection could not be documented, and more intensely in severe sepsis and in patients who died (11%). The slope of the regression line between IL-10 and TNF-alpha was sharper in patients with severe sepsis and in those who died; an imbalance between pro- and anti-inflammatory cytokines may be related to poor prognosis. Increased IL-6 and IL-10, decreased muscle mass, raised BUN and low body temperature were all independently related to prognosis. (C) 2001 Academic Press.

引用

页码：232 / 236

页数：5

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