Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis

被引：63

作者：

Ho, HN ^{[1
]}

Wu, MY ^{[1
]}

Chao, KH ^{[1
]}

Chen, CD ^{[1
]}

Chen, SU ^{[1
]}

Chen, HF ^{[1
]}

Yang, YS ^{[1
]}

机构：

[1] NATL TAIWAN UNIV,COLL MED,DEPT OBSTET & GYNECOL,TAIPEI 10764,TAIWAN

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1996年 / 175卷 / 05期

关键词：

endometriosis; interleukin-6; interferon gamma; T-cell activation; gonadotropin-releasing hormone agonist;

D O I：

10.1016/S0002-9378(96)70034-0

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: Our purpose was to verify regional immune modulations and to test the effect of gonadotropin-releasing hormone agonist in women with endometriosis. STUDY DESIGN: Concentrations of peritoneal cytokines, including interleukin-1 beta, interleukin-2, soluble interleukin-2 receptor, interleukin-6, granulocyte-monocyte colony-stimulating factor, interferon gamma, and tumor necrosis factor-alpha were compared in women with and without endometriosis. Peritoneal cytokine and interleukin-2 production were examined by adding various mitogens to peritoneal fluid mononuclear cells of women with advanced endometriosis before and after gonadotropin-releasing hormone agonist treatment. RESULTS: A significant increase in peritoneal interleukin-1 beta, interleukin-6, and tumor necrosis factor-cc and a decrease in interferon gamma were noted in women with endometriosis. After gonadotropin-releasing hormone agonist treatment interleukin-6 decreased and interferon gamma increased. A significant impairment of interleukin-2 production of peritoneal fluid mononuclear cells by phytohemagglutinin and pokeweed mitogen stimulation was demonstrated in endometriosis, and production could be restored after gonadotropin-releasing hormone agonist treatment. CONCLUSION: These results indicate that regional immunologic dysfunction might be invoked in the disease process of endometriosis.

引用

页码：1236 / 1241

页数：6

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