Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation

被引:220
作者
Kobayashi, K [1 ]
Hatano, M [1 ]
Otaki, M [1 ]
Ogasawara, T [1 ]
Tokuhisa, T [1 ]
机构
[1] Chiba Univ, Grad Sch Med, Dept Dev Genet, Chuo Ku, Chiba 2608670, Japan
关键词
D O I
10.1073/pnas.96.4.1457
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The inhibitor of apoptosis (IAP) proteins form a highly conserved gene family that prevents cell death in response to a variety of stimuli. Herein we describe a newly defined murine IAP, designated Tiap, that proved to be a murine homologue of human survivin based on sequence comparison. TIAP has one baculovirus IAP repeat and lacks a C-terminaI RING finger motif. TIAP interacted with the processed form of caspase 3 and inhibited caspase-induced cell death. Histological examinations revealed that TIAP is expressed in growing tissues such as thymus, testis, and intestine of adult mice and many tissues of embryos. In in vitro studies, TIAP was induced in splenic T cells activated with anti-CD3 antibody or Con A, and the expression of TIAP was up-regulated in synchronized NM 3T3 cells at S to G(2)/M phase of the cell cycle. We propose that during cell proliferation, cellular protective activity may be augmented with inducible IAPs such as TIAP.
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页码:1457 / 1462
页数:6
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