Structure, function and regulation of spliceosomal RNA helicases

被引：82

作者：

Cordin, Olivier ^{[1
]}

Hahn, Daniela ^{[1
]}

Beggs, Jean D. ^{[1
]}

机构：

[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2012年 / 24卷 / 03期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

DEXD/H-BOX ATPASE; G-PATCH PROTEIN; NUCLEAR-RNA; DNA-BINDING; PRP43; PRP16; DYNAMICS; BRR2P; REARRANGEMENT; TRANSLOCATION;

D O I：

10.1016/j.ceb.2012.03.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pre-mRNA splicing requires the activities of several ATPases from the DEAH-box, DEAD-box and Ski2-like helicase families to control conformational rearrangements within the spliceosome. Recent findings indicate that several spliceosomal helicases can act at multiple stages of the splicing reaction, and information on how those multiple actions are controlled are emerging. The recently solved crystal structure of the DEAH-box helicase Prp43 provides novel insights into the similarities and differences between the three helicase families. Here we discuss the potential family-specific mechanisms of spliceosomal RNA helicases and their regulation.

引用

页码：431 / 438

页数：8

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