Synthesis and structure-activity relationships of 2-vinylchroman-4-ones as potent antibiotic agents

被引：92

作者：

Albrecht, U

Lalk, M

Langer, P

机构：

[1] Univ Greifswald, Inst Pharm, D-17487 Greifswald, Germany

[2] Univ Greifswald, Int Chem & Biochem, D-17487 Greifswald, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 05期

关键词：

antibiotics; chromanones; natural product analogues; oxygen heterocycles; pharmacological screening;

D O I：

10.1016/j.bmc.2004.12.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel 2-vinylchroman-4-ones, analogues of the natural products Aposphaerin A and B, were identified as potent antibiotics. Derivatives exhibit a significant activity against multiresistant strains of S. aureus, such as MRSA (methicillin resistant S. aureus). The 2-vinylchroman-4-ones were efficiently prepared by Lewis acid mediated conjugate addition of vinylmagnesium bromide to chromones. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1531 / 1536

页数：6

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