Novel HLA-A and HLA-B alleles

被引：14

作者：

Hurley, CK

Steiner, N

Kosman, C

Mitton, W

Koester, R

Bei, M

Bush, J

McCormack, J

Hahn, A

Henson, V

Hoyer, R

Wade, JA

Hartzman, RJ

Ng, J

机构：

[1] Georgetown Univ, Sch Med, Dept Microbiol & Immunol, Washington, DC USA

[2] USN, Med Res Inst, Bethesda, MD USA

[3] Lab Corp Amer Holdings, Burlington, NC USA

[4] Georgetown Univ, Sch Med, Dept Pediat, Washington, DC 20007 USA

[5] Baylor Univ, Med Ctr, Dallas, TX USA

[6] Albany Med Coll, Albany, NY 12208 USA

[7] Univ Toronto, Toronto Hosp, Reg Histocompatibil Lab, Toronto, ON M5G 2M1, Canada

来源：

TISSUE ANTIGENS | 1998年 / 52卷 / 01期

关键词：

HLA-A; HLA-B; polymorphism;

D O I：

10.1111/j.1399-0039.1998.tb03029.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nine novel HLA-A and HLA-B alleles are described: A*2609, A*6803, A*6806, B*1539, B*1540, B*2712, B*4103, B*5109, and B*5603. Most appear to have arisen by gene conversion events. B*5603 appears to have arisen by a reciprocal recombination event joining exon 2 of a B*55/*56 allele with exon 3 of a B*15 allele. Seroiogically, the antigen encoded by this allele types with broad B22- and Bw6-specific alloantisera. Also unique, the antigen encoded by B*2712 does not react with B27-specific alloantisera but does react with Bw6-specific alloantisera.

引用

页码：84 / 87

页数：4

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