Epigenetic choreographers of neurogenesis in the adult mammalian brain

被引：244

作者：

Ma, Dengke K. ^{[3
]}

Marchetto, Maria Carolina ^{[2
]}

Guo, Junjie U. ^{[1
,4
]}

Ming, Guo-li ^{[1
,4
,5
]}

Gage, Fred H. ^{[2
]}

Song, Hongjun ^{[1
,4
,5
]}

机构：

[1] Johns Hopkins Univ Sch Med, Inst Cell Engn, Baltimore, MD USA

[2] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

[3] MIT, Dept Biol, Cambridge, MA USA

[4] Johns Hopkins Univ Sch Med, Solomon Snyder Dept Neurosci, Baltimore, MD USA

[5] Johns Hopkins Univ Sch Med, Dept Neurol, Baltimore, MD USA

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 11期

基金：

美国国家卫生研究院;

关键词：

NEURAL STEM-CELLS; METHYL-CPG BINDING-PROTEIN-1; CENTRAL-NERVOUS-SYSTEM; SELF-RENEWAL; HIPPOCAMPAL NEUROGENESIS; DNA METHYLATION; PROGENITOR CELLS; GENE-EXPRESSION; L1; RETROTRANSPOSITION; STEM/PROGENITOR CELLS;

D O I：

10.1038/nn.2672

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Epigenetic mechanisms regulate cell differentiation during embryonic development and also serve as important interfaces between genes and the environment in adulthood. Neurogenesis in adults, which generates functional neural cell types from adult neural stem cells, is dynamically regulated by both intrinsic state-specific cell differentiation cues and extrinsic neural niche signals. Epigenetic regulation by DNA and histone modifiers, non-coding RNAs and other self-sustained mechanisms can lead to relatively long-lasting biological effects and maintain functional neurogenesis throughout life in discrete regions of the mammalian brain. Here, we review recent evidence that epigenetic mechanisms carry out diverse roles in regulating specific aspects of adult neurogenesis and highlight the implications of such epigenetic regulation for neural plasticity and disorders.

引用

页码：1338 / 1344

页数：7

共 100 条

[1] The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits [J].