Cardiovascular risk profile before coronary artery bypass graft surgery in relation to depression and anxiety disorders: An age and sex propensity matched study

被引:21
作者
Tully, Phillip J. [1 ,2 ]
Newland, Richard F. [1 ]
Baker, Robert A. [1 ]
机构
[1] Flinders Med Ctr, Dept Surg, Cardiac Surg Res, Bedford Pk, SA, Australia
[2] Univ Adelaide, Discipline Med, Sch Med, Freemasons Fdn,Ctr Mens Hlth, Adelaide, SA 5005, Australia
基金
澳大利亚国家健康与医学研究理事会;
关键词
Depressive disorder; Anxiety disorders; Coronary artery bypass; Cardiopulmonary bypass; CARDIOPULMONARY BYPASS; PREOPERATIVE ANXIETY; PLATELET REACTIVITY; CABG SURGERY; MORBIDITY; MORTALITY; SYMPTOMS; OUTCOMES; ASSOCIATION; CARE;
D O I
10.1016/j.aucc.2014.04.006
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Objective: The cardiovascular risk profile and postoperative morbidity outcomes of anxiety disorder patients undergoing coronary artery bypass surgery is not known. Methods: In a cross-sectional design, 114 consecutive coronary artery bypass graft surgery patients were evaluated to create four matched groups (30 with anxiety disorder, 27 with depression disorder and 57 age-sex matched coronary artery bypass surgery control patients with no depression or anxiety disorder). Results: By comparison to non-depression disorder age-sex matched controls, depressed patients presented for coronary artery bypass surgery with significantly greater myocardial inflammatory markers (Troponin T > 02, 33.3% vs. 11.1%, p = .03), metabolic risk (body surface area > 35 (22.2% vs. 0%, p = .03), comorbid cardiovascular risk (peripheral vascular disease 18.5% vs. 0%, p = .05). Depressed patients also recorded longer intraoperative time at higher temperatures >37 degrees C on cardiopulmonary bypass (11.1 +/- 9.0 vs. 6.0 +/- 4.9, p < 005) and had higher maximum postoperative Troponin T (.44 +/- .2 vs..28 +/- .1, p = .03). Patients with anxiety disorder on the other hand presented with significantly higher Creatinine Kinase-Muscle Brain (5 IQR 4-5 ng/ml vs. 4 IQR 3-4 ng/ml, p = .04), higher intraoperative glucose levels (7.8 +/- 2.5 mmol/l vs. 7.0 +/- 1.2 mmol/l, p = .05), and received fewer grafts (2.1 +/- .9 vs. 2.5 +/- .9 p = .04). Conclusions: A differential cardiovascular risk profile and postoperative outcome was observed dependent on anxiety and depression disorder status. There were few modifiable cardiovascular risk factors at the time of surgery other than psychiatric status, perioperative management of depression and anxiety may have promise to reduce further cardiac morbidity after coronary artery bypass surgery. Crown Copyright (C) 2014 Published by Elsevier Australia (a division of Reed International Books Australia Pty Ltd) on behalf of Australian College of Critical Care Nurses Ltd. All rights reserved.
引用
收藏
页码:24 / 30
页数:7
相关论文
共 52 条
[1]   A practical approach to assess depression risk and to guide risk reduction strategies in later life [J].
Almeida, Osvaldo P. ;
Alfonso, Helman ;
Pirkis, Jane ;
Kerse, Ngaire ;
Sim, Moira ;
Flicker, Leon ;
Snowdon, John ;
Draper, Brian ;
Byrne, Gerard ;
Goldney, Robert ;
Lautenschlager, Nicola T. ;
Stocks, Nigel ;
Scazufca, Marcia ;
Huisman, Martijn ;
Araya, Ricardo ;
Pfaff, Jon .
INTERNATIONAL PSYCHOGERIATRICS, 2011, 23 (02) :280-291
[2]  
[Anonymous], 2005, Australian Critical Care
[3]   Preoperative depression and mortality in coronary artery bypass surgery: Preliminary findings [J].
Baker, RA ;
Andrew, MJ ;
Schrader, G ;
Knight, JL .
AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY, 2001, 71 (03) :139-142
[4]   Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients [J].
Bankier, Bettina ;
Barajas, Justine ;
Martinez-Rumayor, Abelardo ;
Januzzi, James L. .
EUROPEAN HEART JOURNAL, 2008, 29 (18) :2212-2217
[5]   The relationship between subtypes of depression and cardiovascular disease: a systematic review of biological models [J].
Baune, B. T. ;
Stuart, M. ;
Gilmour, A. ;
Wersching, H. ;
Heindel, W. ;
Arolt, V. ;
Berger, K. .
TRANSLATIONAL PSYCHIATRY, 2012, 2 :e92-e92
[6]   Depression and cardiac morbidity 5 years after coronary artery bypass surgery [J].
Borowicz, L ;
Royall, R ;
Grega, M ;
Selnes, O ;
Lyketsos, C ;
McKhann, G .
PSYCHOSOMATICS, 2002, 43 (06) :464-471
[7]   Study protocol: Intensive care anxiety and emotional recovery (Icare)-A prospective study [J].
Castillo, Maria I. ;
Aitken, Leanne M. ;
Cooke, Marie L. .
AUSTRALIAN CRITICAL CARE, 2013, 26 (03) :142-147
[8]   Relation between depression after coronary artery bypass surgery and 12-month outcome: a prospective study [J].
Connerney, I ;
Shapiro, PA ;
McLaughlin, JS ;
Bagiella, E ;
Sloan, RP .
LANCET, 2001, 358 (9295) :1766-1771
[9]   Cerebral hyperthermia during cardiopulmonary bypass in adults [J].
Cook, DJ ;
Orszulak, TA ;
Daly, RC ;
Buda, DA .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1996, 111 (01) :268-269
[10]   The impact of preoperative anxiety and education level on long-term mortality after cardiac surgery [J].
Cserep, Zsuzsanna ;
Losoncz, Eszter ;
Balog, Piroska ;
Szili-Toeroek, Tamas ;
Husz, Andras ;
Juhasz, Boglarka ;
Kertai, Miklos D. ;
Gal, Janos ;
Szekely, Andrea .
JOURNAL OF CARDIOTHORACIC SURGERY, 2012, 7