Inflammation and gliosis in neurological diseases - clinical implications

被引：66

作者：

Czlonkowska, Anna ^{[1
,2
]}

Kurkowska-Jastrzebska, Iwona ^{[1
]}

机构：

[1] Inst Psychiat & Neurol, Dept Neurol 2, Warsaw, Poland

[2] Med Univ Warsaw, Dept Clin & Expt Pharmacol, Warsaw, Poland

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 231卷 / 1-2期

关键词：

Neurodegeneration; Multiple sclerosis; Parkinson's disease; Alzheimer's disease; Stroke; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; APPEARING WHITE-MATTER; AMYLOID-BETA PEPTIDE; PARKINSONS-DISEASE; MULTIPLE-SCLEROSIS; MOUSE MODEL; MICROGLIAL ACTIVATION; T-CELLS; DOPAMINERGIC-NEURONS; ALZHEIMER-DISEASE;

D O I：

10.1016/j.jneuroim.2010.09.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The inflammatory reaction accompany all acute processes in the central nervous system (CNS), (as stroke or traumatic brain injury) and chronic neurodegenerative processes (as Parkinson's or Alzheimer's disease), and through the stage of cleaning of damage tissue, contribute to recovery and regeneration and eventually to restoration of the function. However many studies showed that inflammation in the CNS may be harmful because of an excessive vulnerability of the nervous tissue or impaired regulation. Manipulation of the inflammation is now one of the approaches in the treatment of the various diseases of the CNS. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：78 / 85

页数：8

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