Ferrocene-functionalized cationic polythiophene for the label-free electrochemical detection of DNA

被引：88

作者：

Le Floch, F

Ho, HA

Harding-Lepage, P

Bédard, M

Neagu-Plesu, R

Leclerc, M ^{[1
]}

机构：

[1] Univ Laval, Canada Res Chair Electroact & Photoact Polymers, Dept Chim, Quebec City, PQ G1K 7P4, Canada

[2] Univ Laval, CERSIM, Dept Chim, Quebec City, PQ G1K 7P4, Canada

来源：

ADVANCED MATERIALS | 2005年 / 17卷 / 10期

关键词：

D O I：

10.1002/adma.200401474

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Specific, sensitive detection of unlabeled target DNA at room temperature is reported. A new, water-soluble, ferrocene-functionalized, cationic polythiophene is synthesized. This conducting polymer, used together with gold-bound peptide nucleic acid (PNA) probes, makes, by a simple electrostatic method, DNA detection possible (see Figure).

引用

页码：1251 / +

页数：5

共 24 条

[1]

ALVAREZ PS, 2004, ANAL BIOANAL CHEM, V378, P104

[2] Trace analysis of an oligonucleotide with a specific sequence using PNA-based ion-channel sensors [J].