Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies

被引：79

作者：

Crespel, A

Genton, P

Berramdane, M

Coubes, P

Monicard, C

Baldy-Moulinier, M

Gelisse, P

机构：

[1] Hop Gui de Chauliac, Epilepsy Unit, F-34295 Montpellier, France

[2] Ctr St Paul H Gastaut, Marseille, France

来源：

NEUROLOGY | 2005年 / 65卷 / 05期

关键词：

D O I：

10.1212/01.wnl.0000174517.21383.36

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ). In three patients, LTG exacerbated MJ in a dose-dependent manner with early aggravation during titration. MJ disappeared when LTG dose was decreased by 25 to 50%. In two patients, LTG exacerbated MJ in a delayed but more severe manner, with myoclonic status that only ceased after LTG withdrawal.

引用

页码：762 / 764

页数：3

共 10 条

[1]

Biraben A, 2000, NEUROLOGY, V55, P1758

[2]

Carrazana EJ, 2001, NEUROLOGY, V56, P1424, DOI 10.1212/WNL.56.10.1424-a

[3] Clinical factors of drug resistance in juvenile myoclonic epilepsy [J].