Clinical studies implementing glutamate neurotransmission in mood disorders

被引：119

作者：

Sanacora, G

Rothman, DL

Mason, G

Krystal, JH

机构：

[1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06519 USA

[2] Yale Univ, Sch Med, Dept Radiol, New Haven, CT 06519 USA

来源：

GLUTAMATE AND DISORDERS OF COGNITION AND MOTIVATION | 2003年 / 1003卷

关键词：

mood disorders; glutamate neurotransmission;

D O I：

10.1196/annals.1300.018

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Emerging evidence suggests that the amino acid neurotransmitter systems are associated with the pathophysiology and treatment of mood disorders. Recent advances in the areas of molecular neurobiology, pharmacology, and magnetic resonance spectroscopy (MRS) now provide better tools to probe the function of the amino acid neurotransmitter systems and are affording us the opportunity to better investigate the relationship of these systems to mood disorders. Here we review the available literature in the field and suggest a possible pathophysiological model that may account for the many of the findings.

引用

收藏

页码：292 / 308

页数：17

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