Spherical Nucleic Acids

被引：912

作者：

Cutler, Joshua I.

Auyeung, Evelyn

Mirkin, Chad A. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 03期

关键词：

MODIFIED GOLD-NANOPARTICLE; COLORIMETRIC DETECTION; ASYMMETRIC FUNCTIONALIZATION; STRUCTURAL-CHARACTERIZATION; SCAVENGER RECEPTORS; OPTICAL-PROPERTIES; PARTICLE-SIZE; DNA DETECTION; CAGED DIMERS; NANO-FLARES;

D O I：

10.1021/ja209351u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them. Important examples of technological advances made possible by their fundamental properties spanning the fields of chemistry, molecular diagnostics, gene regulation, medicine, and materials science are also presented.

引用

收藏

页码：1376 / 1391

页数：16

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