Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study

被引：133

作者：

Caslake, Muriel J. ^{[1
]}

Miles, Elizabeth A. ^{[2
]}

Kofler, Bettina M. ^{[5
]}

Lietz, Georg ^{[4
]}

Curtis, Peter ^{[4
]}

Armah, Christopher K. ^{[5
]}

Kimber, Alan C. ^{[3
]}

Grew, Jilly P. ^{[5
]}

Farrell, Lesley ^{[1
]}

Stannard, Julie ^{[4
]}

Napper, Frances L. ^{[2
]}

Sala-Vila, Aleix ^{[2
]}

West, Annette L. ^{[2
]}

Mathers, John C. ^{[4
]}

Packard, Christopher ^{[1
]}

Williams, Christine M. ^{[5
]}

Calder, Philip C. ^{[2
]}

Minihane, Anne M. ^{[5
]}

机构：

[1] Univ Glasgow, Dept Vasc Biochem, Fac Med, Glasgow, Lanark, Scotland

[2] Univ Southampton, Inst Human Nutr, Sch Med, Southampton, Hants, England

[3] Univ Reading, Quantitat Biol & Appl Stat Sect, Sch Biol Sci, Reading RG6 6AP, Berks, England

[4] Univ Newcastle Upon Tyne, Human Nutr Res Ctr, Sch Clin Med Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[5] Univ Reading, Hugh Sinclair Human Nutr Grp, Sch Chem Food Biosci & Pharm, Reading RG6 6AP, Berks, England

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2008年 / 88卷 / 03期

关键词：

D O I：

10.1093/ajcn/88.3.618

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Background: The lipid-modulatory effects of high intakes of the fish-oil fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are well established and likely to contribute to cardioprotective benefits. Objectives: We aimed to determine the effect of moderate EPA and DHA intakes (< 2 g EPA + DHA/d) on the plasma fatty acid profile, lipid and apolipoprotein concentrations, lipoprotein subclass distribution, and markers of oxidative status. We also aimed to examine the effect of age, sex, and apolipoprotein E (APOE) genotype on the observed responses. Design: Three hundred twelve adults aged 20-70 y, who were prospectively recruited according to age, sex, and APOE genotype, completed a double-blind placebo-controlled crossover study. Participants consumed control oil, 0.7 g EPA + DHA/d (0.7FO), and 1.8 g EPA + DHA/d (1.8FO) capsules in random order, each for an 8-wk intervention period, separated by 12-wk washout periods. Results: In the group as a whole, 8% and 11% lower plasma triacylglycerol concentrations were evident after 0.7FO and 1.8FO, respectively (P < 0.001): significant sex x treatment (P = 0.038) and sex x genotype x treatment (P = 0.032) interactions were observed, and the greatest triacylglycerol-lowering responses (reductions of 15% and 23% after 0.7FO and 1.8FO, respectively) were evident in APOE4 men. Furthermore, lower VLDL-cholesterol (P = 0.026) and higher LDL-cholesterol (P = 0.010), HDL-cholesterol (P < 0.001), and HDL2 (P < 0.001) concentrations were evident after fish-oil intervention. Conclusions: Supplements providing EPA + DHA at doses as low as 0.7 g/d have a significant effect on the plasma lipid profile. The results of the current trial, which used a prospective recruitment approach to examine the responses in population subgroups, are indicative of a greater triacylglycerol-lowering action of long-chain n-3 polyunsaturated fatty acids in males than in females.

引用

页码：618 / 629

页数：12

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