Ubiquilin at a crossroads in protein degradation pathways

被引：37

作者：

Rothenberg, Cara ^{[1
]}

Monteiro, Mervyn J. ^{[1
]}

机构：

[1] Univ Maryland, Ctr Biomed Engn & Technol, Dept Anat & Neurol, Baltimore, MD 21201 USA

来源：

AUTOPHAGY | 2010年 / 6卷 / 07期

关键词：

autophagy; cell death; LC3; protein turnover; ubiquitin;

D O I：

10.4161/auto.6.7.13118

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ubiquilin proteins are conserved across all eukaryotes and function in the regulation of protein degradation. We found that ubiquilin functions to regulate macroautophagy and that the protein is also a substrate of chaperone-mediated autophagy.

引用

页码：979 / 980

页数：2