Expression of TGF-beta type I and type II receptors in rat eyes

被引：30

作者：

Obata, H ^{[1
]}

Kaburaki, T ^{[1
]}

Kato, M ^{[1
]}

Yamashita, H ^{[1
]}

机构：

[1] JAPANESE FDN CANC RES,INST CANC,DEPT BIOCHEM,TOKYO 170,JAPAN

来源：

CURRENT EYE RESEARCH | 1996年 / 15卷 / 03期

关键词：

immunohistochemistry; rat eye; serine/threonine kinase receptor; transforming growth factor-beta (TGF-beta); TGF-beta receptors;

D O I：

10.3109/02713689609007629

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Transforming growth factor beta (TGF-beta) transduces signals through mediation of type I and type II serine/threonine kinase receptors. The expression of TGF-beta type I (T beta R-I) and II (T beta R-II) receptors in rat eyes was investigated immunohistochemically. T beta R-I and T beta R-II immunoreactivity was detected in corneal and conjunctival epithelial cells, corneal endothelial cells, ciliary epithelial cells, lens epithelial cells, retinal pigment epithelial cells, and choroidal vessels. This co-expression of T beta R-I and T beta R-II indicates that the above cells respond to TGF-beta and, because TGF-beta is reported to be produced in ocular tissues, that it may have important autocrine and/or paracrine roles in the growth and metabolism of ocular tissues in situ.

引用

页码：335 / 340

页数：6

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