Procalcitonin as an early indicator of outcome in sepsis: a prospective observational study

被引：38

作者：

Giamarellos-Bourboulis, E. J. ^{[1
]}

Tsangaris, I. ^{[2
]}

Kanni, Th. ^{[1
]}

Mouktaroudi, M. ^{[1
]}

Pantelidou, I. ^{[1
]}

Adamis, G. ^{[3
]}

Atmatzidis, S. ^{[4
]}

Chrisofos, M. ^{[5
]}

Evangelopoulou, V. ^{[6
]}

Frantzeskaki, F. ^{[2
]}

Giannopoulos, P. ^{[7
]}

Giannikopoulos, G. ^{[8
]}

Gialvalis, D. ^{[9
]}

Gourgoulis, G. M. ^{[1
]}

Kotzampassi, K. ^{[10
]}

Katsifa, K. ^{[11
]}

Kofinas, G. ^{[12
]}

Kontopidou, F. ^{[1
]}

Koratzanis, G. ^{[13
]}

Koulouras, V. ^{[14
]}

Koutsikou, A. ^{[15
]}

Koupetori, M. ^{[16
]}

Kritselis, I. ^{[17
]}

Leonidou, L. ^{[18
]}

Mega, A. ^{[19
]}

Mylona, V. ^{[13
]}

Nikolaou, H. ^{[20
]}

Orfanos, S. ^{[2
]}

Panagopoulos, P. ^{[1
]}

Paramythiotou, E. ^{[2
]}

Papadopoulos, A. ^{[1
]}

Papanikolaou, X. ^{[12
]}

Pavlaki, M. ^{[21
]}

Polychronopoulos, V. ^{[22
]}

Skoutelis, A. ^{[23
]}

Theodotou, A. ^{[24
]}

Vassiliaghou, M. ^{[25
]}

Douzinas, E. E. ^{[26
]}

Gogos, C. ^{[18
]}

Armaganidis, A. ^{[2
]}

机构：

[1] Univ Athens, Sch Med, Dept Internal Med 4, GR-11527 Athens, Greece

[2] Univ Athens, Sch Med, Dept Crit Care 2, GR-11527 Athens, Greece

[3] G Gennimatas Athens Hosp, Dept Internal Med 1, Athens, Greece

[4] Univ Thessaloniki, Sch Med, Dept Surg 2, GR-54006 Thessaloniki, Greece

[5] Sismanogleion Athens Hosp, Dept Urol 2, Athens, Greece

[6] Korgialeneion Benakeion Hosp Athens, Intens Care Unit, Athens, Greece

[7] Univ Athens, Sch Med, Dept Propedeut Surg 1, GR-11527 Athens, Greece

[8] Chios Gen Hosp, Dept Internal Med, Chios, Greece

[9] Evangelismos Athens Gen Hosp, Dept Surg 2, Athens, Greece

[10] Univ Thessaloniki, Med Sch Thessaloniki, Dept Prop Surg 1, Thessaloniki, Greece

[11] Tzaneion Hosp Piraeus, Intens Care Unit, Piraeus, Greece

[12] Hippokrateion Athens Gen Hosp, Intens Care Unit, Athens, Greece

[13] Sismanogleion Athens Hosp, Dept Internal Med 2, Athens, Greece

[14] Univ Ioannina, Sch Med, Dept Crit Care, GR-45110 Ioannina, Greece

[15] Thriassio Elefsina Gen Hosp, Intens Care Unit, Elefsina, Greece

[16] Thriassio Elefsina Gen Hosp, Dept Internal Med 1, Elefsina, Greece

[17] Nafplion Gen Hosp, Dept Surg, Nafplion, Greece

[18] Univ Patras, Sch Med, Dept Internal Med 1, GR-26110 Patras, Greece

[19] Laikon Athens Gen Hosp, Intens Care Unit, Athens, Greece

[20] Aghia Olga Athens Gen Hosp, Intens Care Unit, Athens, Greece

[21] Argos Gen Hosp, Dept Internal Med, Argos, Greece

[22] Sismanoglion Athens Hosp, Dept Pulm Med 3, Athens, Greece

[23] Evangelismos Athens Hosp, Dept Internal Med 5, Athens, Greece

[24] Karditsa Gen Hosp, Intens Care Unit, Kardhitsa, Greece

[25] G Gennimatas Thessaloniki Gen Hosp, Intens Care Unit, Thessaloniki, Greece

[26] Univ Athens, Sch Med, Dept Crit Care 3, GR-11527 Athens, Greece

来源：

JOURNAL OF HOSPITAL INFECTION | 2011年 / 77卷 / 01期

关键词：

Procalcitonin; Prognosis; Sepsis; RESPIRATORY-TRACT INFECTIONS; CRITICALLY-ILL PATIENTS; ANTIBIOTIC-THERAPY; DIAGNOSIS; PNEUMONIA; GUIDANCE;

D O I：

10.1016/j.jhin.2010.07.026

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

This study explores the role of procalcitonin (PCT) in predicting the outcome of sepsis. In a prospective multicentre observational investigation, blood was sampled within 24 h of onset of sepsis in 1156 hospitalised patients; 234 were in the intensive care unit (ICU) at the point of presentation of sepsis while 922 were not. PCT was estimated in serum by the ultrasensitive Kryptor assay in a double-blinded fashion. Among patients outside the ICU, mortality was 8% in those with PCT <= 0.12 ng/mL but 19.9% in those with PCT >0.12 ng/mL [P < 0.0001, odds ratio (OR) for death: 2.606; 95% confidence interval (CI): 1.553-4.371]. Among patients whose sepsis presented in ICU, mortality was 25.6% in those with PCT <= 0.85 ng/mL but 45.3% in those with PCT >0.85 ng/mL (P = 0.002; OR for death: 2.404; 95% CI: 1.385-4.171). It is concluded that PCT cut-off concentrations can contribute to predicting the outcome of sepsis and might be of particular value in identifying patients who would benefit from ICU admission. (C) 2010 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：58 / 63

页数：6

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