Can cell systems biology rescue drug discovery?

被引：185

作者：

Butcher, EC ^{[1
]}

机构：

[1] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2005年 / 4卷 / 06期

关键词：

D O I：

10.1038/nrd1754

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

The focus of innovation in current drug discovery is on new targets, yet compound efficacy and safety in biological models of disease-not target selection-are the criteria that determine which drug candidates enter the clinic. We consider a biology-driven approach to drug discovery that involves screening compounds by automated response profiling in disease models based on complex human-cell systems. Drug discovery through cell systems biology could significantly reduce the time and cost of new drug development.

引用

收藏

页码：461 / 467

页数：7

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