Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar β-amyloid

被引：106

作者：

Husemann, J

Loike, JD

Kodama, T

Silverstein, SC

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Physiol & Cellular Biophys, New York, NY 10032 USA

[2] Univ Tokyo, Adv Sci & Technol Res Ctr, Dept Mol Biol & Med, Tokyo, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 114卷 / 1-2期

关键词：

Alzheimer's disease; microglia; amyloid; scavenger receptor; SR-BI; reactive oxygen species; fucoidan;

D O I：

10.1016/S0165-5728(01)00239-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Class A scavenger receptors (SR-A) mediate microglial interaction with fibrillar beta -amyloid (fA beta). We report here that neonatal microglia from SR-A knockout mice (SR-A(-/-)) adhere to surface-bound fA beta, and produce reactive oxygen species (ROS) as efficiently as wildtype microglia; that both wildtype and SR-A(-/-) microglia express SR-BI; that antibodies against SR-BI do not affect adhesion or ROS production by wildtype microglia, but inhibit adhesion and ROS production of SR-A(-/-) microglia to immobilized fA beta by similar to 40%. Adhesion to fA beta -coated surfaces, and uptake of fA beta by both wildtype and SR-A(-/-) microglia was almost completely inhibited by incubation with fucoidan. Thus SR-BI and SR-A mediate similar effector functions in neonatal microglia, which suggests that SR-BI plays as important a role as SR-A, and can maintain the wildtype phenotype in SR-A(-/-) microglia. (C) 2001 Elsevier Science BN. All rights reserved.

引用

页码：142 / 150

页数：9

共 27 条

[1] Engagement of the scavenger receptor is not responsible for β-amyloid stimulation of monocytes to a neurocytopathic state [J].