First examples of peptidomimetic inhibitors of interleukin-1 beta converting enzyme

被引：45

作者：

Dolle, RE ^{[1
]}

Prouty, CP ^{[1
]}

Prasad, CVC ^{[1
]}

Cook, E ^{[1
]}

Saha, A ^{[1
]}

Ross, TM ^{[1
]}

Salvino, JM ^{[1
]}

Helaszek, CT ^{[1
]}

Ator, MA ^{[1
]}

机构：

[1] SANOFI WINTHROP INC,COLLEGEVILLE,PA 19426

来源：

关键词：

PROTEASE; PRECURSOR;

D O I：

10.1021/jm9601516

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：2438 / 2440

页数：3

共 24 条

[1] NONPEPTIDIC INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE .3. DESIGN, SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, AND STRUCTURE-ACTIVITY-RELATIONSHIPS FOR A SERIES OF ORALLY-ACTIVE 3-AMINO-6-PHENYLPYRIDIN-2-ONE TRIFLUOROMETHYL KETONES
BERNSTEIN, PR
ANDISIK, D
BRADLEY, PK
BRYANT, CB
CECCARELLI, C
DAMEWOOD, JR
EARLEY, R
EDWARDS, PD
FEENEY, S
GOMES, BC
KOSMIDER, BJ
STEELMAN, GB
THOMAS, RM
VACEK, EP
VEALE, CA
WILLIAMS, JC
WOLANIN, DJ
WOOLSON, SA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (20) : 3313 - 3326
[2] BERNSTEIN PR, 1993, Patent No. 9321209
[3] BERNSTEIN PR, 1993, Patent No. 9321214
[4] BERNSTEIN PR, 1993, Patent No. 9321210
[5] ACTIVATION OF INTERLEUKIN-1-BETA BY A CO-INDUCED PROTEASE
BLACK, RA
KRONHEIM, SR
SLEATH, PR
[J]. FEBS LETTERS, 1989, 247 (02) : 386 - 390
[6] BLACK RA, 1988, J BIOL CHEM, V263, P9437
[7] DESIGN OF ORALLY-ACTIVE, NONPEPTIDIC INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE
BROWN, FJ
ANDISIK, DW
BERNSTEIN, PR
BRYANT, CB
CECCARELLI, C
DAMEWOOD, JR
WOOLSON, SA
EDWARDS, PD
EARLEY, RA
FEENEY, S
GREEN, RC
GOMES, B
KOSMIDER, BJ
KRELL, RD
SHAW, A
STEELMAN, GB
THOMAS, RN
VACEK, EP
VEALE, CA
TUTHILL, PA
WARNER, P
WILLIAMS, JC
WOLANIN, DJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (09) : 1259 - 1261
[8] DINARELLO CA, 1991, BLOOD, V77, P1627
[9] DINARELLO CA, 1993, NEW ENGL J MED, V328, P106
[10] BLOCKING IL-1 - INTERLEUKIN-1 RECEPTOR ANTAGONIST INVIVO AND INVITRO
DINARELLO, CA
THOMPSON, RC
[J]. IMMUNOLOGY TODAY, 1991, 12 (11): : 404 - 410