The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by 1,25-Dihydroxyvitamin D3

被引:274
作者
Pike, J. Wesley [1 ]
Meyer, Mark B. [1 ]
机构
[1] Univ Wisconsin Madison, Dept Biochem, Madison, WI 53706 USA
基金
美国国家卫生研究院;
关键词
Transcription; ChIP-chip analysis; Distal enhancers; RNA polymerase II; Histone H4 acetylation; VDR gene; KAPPA-B LIGAND; DISTANT TRANSCRIPTIONAL ENHANCER; POTENTIAL VANILLOID TYPE-6; HUMAN OSTEOCALCIN GENE; D-RESPONSIVE ELEMENT; CASEIN KINASE-II; PARATHYROID-HORMONE; BINDING-SITES; SEQUENCE ELEMENTS; NUCLEAR RECEPTOR;
D O I
10.1016/j.ecl.2010.02.007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The actions of the vitamin D hormone 1,25-dihydroxyvitamin D-3 (1,25(OH2D3) are mediated by the vitamin D receptor (VDR), a ligand-activated transcription factor that functions to control gene expression. After ligand activation, the VDR binds directly to specific sequences located near promoters and recruits a variety of coregulatory complexes that perform the additional functions required to modify transcriptional output. Recent advances in transcriptional regulation, which permit the unbiased identification of the regulatory regions of genes, are providing new insight into how genes are regulated. Surprisingly, gene regulation requires the orchestrated efforts of multiple modular enhancers often located many kilobases upstream, downstream, or within the transcription units themselves. These studies are transforming our understanding of how 1,25(OH)(2)D-3 regulates gene transcription.
引用
收藏
页码:255 / +
页数:16
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