Halogenation of N6-benzyladenosine decreases its cytotoxicity in human leukemia cells

被引：7

作者：

Dolezel, Petr ^{[1
]}

Koudelkova, Petra ^{[1
]}

Mlejnek, Petr ^{[1
]}

机构：

[1] Palacky Univ, Fac Med & Dent, Dept Biol, Olomouc 77515, Czech Republic

来源：

TOXICOLOGY IN VITRO | 2010年 / 24卷 / 08期

关键词：

Adenosine kinase; U937; cells; Apoptosis; Purines; ADENOSINE KINASE; HL-60; CELLS; APOPTOSIS; INDUCTION; DERIVATIVES; CYTOKININS; INHIBITORS; AGONISTS;

D O I：

10.1016/j.tiv.2010.07.010

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Cytotoxicity of two halogen derivatives of N-6-benzyladenosine (BAPR), N-6-(3-iodobenzyl)-adenosine (I-BAPR) and 2-chloro-N-6-(3-iodobenzyl)-adenosine (Cl-I-BAPR), was tested in human leukemia U937 cell line. Our results revealed that their cytotoxicity was surprisingly low. I-BAPR and also Cl-I-BAPR induced cell death with morphological and biochemical hallmarks of apoptosis, although the number of apoptotic cells was significantly lower than that found for BAPR. Our data strongly suggested that the decreased cytotoxic effect of halogenated derivatives of N-6-benzyladenosine was related to their reduced intracellular phosphorylation by adenosine kinase. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2079 / 2083

页数：5

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