Early pregnancy blood lead levels and the risk of premature rupture of the membranes

被引：45

作者：

Vigeh, Mohsen ^{[1
]}

Yokoyama, Kazuhito ^{[2
]}

Shinohara, Atsuko ^{[2
]}

Afshinrokh, Mohammadreza ^{[3
]}

Yunesian, Masoud ^{[4
]}

机构：

[1] NIOSH, Dept Hazard Assessment, Tama Ku, Kawasaki, Kanagawa 2148585, Japan

[2] Juntendo Univ Fac Med, Dept Epidemiol & Environm Hlth, Bunkyo Ku, Tokyo 1138421, Japan

[3] Univ Tehran Med Sci, Tehran, Iran

[4] Univ Tehran Med Sci, Environm Res Ctr, Tehran, Iran

来源：

REPRODUCTIVE TOXICOLOGY | 2010年 / 30卷 / 03期

基金：

日本学术振兴会;

关键词：

Lead; Pregnancy; Fetal membrane; Premature rupture of the membranes; HYPERTENSION; EXPOSURE; ETIOLOGY; POSTPARTUM; TOXICITY; CHILDREN; OUTCOMES; TEHRAN; WOMEN; CITY;

D O I：

10.1016/j.reprotox.2010.05.007

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

To clarify the effects of lead on fetal premature rupture of the membranes (PROM), blood lead concentrations were measured using inductively coupled plasma-mass spectrometry in 332 women, aged 16-35 years, during their early pregnancy period (8-12 weeks). Blood lead concentrations were significantly higher in the 36 PROM deliveries than in the 296 non-PROM deliveries (mean +/- SD, 4.61 +/- 2.37 and 3.69 +/- 1.85 mu g/dl, respectively; p < 0.05). The logistic regression analysis revealed that a 1-unit increase in the logarithm of the blood lead level led to a several-fold increase in the risk of PROM (unit risk = 17.98, 95% CI 1.6-198.6). Thus, it is suggested that lead can increase the risk of PROM in pregnant women with mean blood lead less than 5 mu g/dl. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：477 / 480

页数：4

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