Histone lysine demethylases: emerging roles in development, physiology and disease

被引：438

作者：

Shi, Yang ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 11期

关键词：

D O I：

10.1038/nrg2218

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The discovery of an increasing number of histone demethylases has highlighted the dynamic nature of the regulation of histone methylation, a key chromatin modification that is involved in eukaryotic genome and gene regulation. A flurry of recent studies has offered glimpses into the specific biological roles of these enzymes and their potential connections to human diseases. These advances have also catalysed a resurgence of interest in epigenetic regulators as potential therapeutic targets.

引用

页码：829 / 833

页数：5

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