A combinatorial synthesis of a macrosphelide library utilizing a palladium-catalyzed carbonylation on a polymer support

被引：85

作者：

Takahashi, T

Kusaka, S

Doi, T

Sunazuka, T

Omura, S

机构：

[1] Tokyo Inst Technol, Dept Appl Chem, Tokyo 1528552, Japan

[2] Kitasato Univ, Kitasato Inst Life Sci, Tokyo 1088641, Japan

[3] Kitasato Univ, Sch Pharmaceut Sci, Tokyo 1088641, Japan

[4] Kitasato Inst Shirokane, Tokyo 1088641, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 42期

关键词：

chemoselectivity combinatorial chemistry macrosphelides; palladium; solid-phase synthesis;

D O I：

10.1002/anie.200352229

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Supported total synthesis: The combinatorial synthesis of a 122-membered macrosphelide library including macrosphelides A, C, E, and F (see picture) has been achieved based on a unique strategy for a three-component coupling utilizing a palladium-catalyzed chemoselective carbonylation and an unprecedented macrolactonization on a polymer support.

引用

页码：5230 / 5234

页数：5

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