Salidroside Attenuates Hydrogen Peroxide-Induced Cell Damage Through a cAMP-Dependent Pathway

被引：17

作者：

Guan, Shuang ^{[1
]}

Wang, Wei ^{[1
]}

Lu, Jing ^{[1
,2
]}

Qian, Wenhui ^{[2
]}

Huang, Guoren ^{[2
]}

Deng, Xuming ^{[1
]}

Wang, Xuelin ^{[1
]}

机构：

[1] Jilin Univ, Coll Anim Sci & Vet Med, Inst Zoonoses, Changchun 130062, Jilin, Peoples R China

[2] Jilin Univ, Lab Nutr & Funct Food, Changchun 130062, Jilin, Peoples R China

来源：

MOLECULES | 2011年 / 16卷 / 04期

关键词：

salidroside; antioxidant; AMP; cGMP; Ca2+]i; ROS; ISCHEMIA/REPERFUSION INJURY; RHODIOLA-ROSEA; IN-VITRO; APOPTOSIS; KINASE; MICE; CGMP;

D O I：

10.3390/molecules16043371

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Salidroside, a major component of Rhodiola rosea L., has shown various pharmacological functions, including antioxidant effects, but the signal transduction pathway of its antioxidant effects is not very clear. In this study, we found that salidroside could attenuate hydrogen peroxide (H2O2)-induced HL-7702 cell damage, inhibit H2O2-induced cytosolic free Ca2+ ([Ca2+]i) elevation, scavenge reactive oxygen species (ROS) and increase 3'-5'-cyclic adenosine monophosphate (cAMP) level in a dose-dependent manner, but it couldn't influence 3'-5'-cyclic guanosine monophosphate (cGMP) levels. Therefore, these results indicated that the antioxidant effects of salidroside were associated with down-regulation of [Ca2+] i, ROS occur via a cAMP-dependent pathway.

引用

页码：3371 / 3379

页数：9

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