Will cancer stem cells provide new therapeutic targets?

被引:111
作者
Behbod, F [1 ]
Rosen, JM [1 ]
机构
[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
关键词
D O I
10.1093/carcin/bgh293
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This review presents a brief synopsis of recent progress in the area of cancer stem cells, with emphasis on leukemia and breast cancer, and discusses potential limitations to accomplishing the ultimate goal of eradicating residual disease in cancer.
引用
收藏
页码:703 / 711
页数:9
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共 78 条
  • [1] Prospective identification of tumorigenic breast cancer cells
    Al-Hajj, M
    Wicha, MS
    Benito-Hernandez, A
    Morrison, SJ
    Clarke, MF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) : 3983 - 3988
  • [2] Alvi AJ, 2003, BREAST CANCER RES, V5, DOI [10.1186/bcr563, 10.1186/bcr547]
  • [3] CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?
    Arias, AM
    Zecchini, V
    Brennan, K
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (05) : 524 - 533
  • [4] Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
    Ayton, PM
    Cleary, ML
    [J]. GENES & DEVELOPMENT, 2003, 17 (18) : 2298 - 2307
  • [5] Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
    Ayton, PM
    Cleary, ML
    [J]. ONCOGENE, 2001, 20 (40) : 5695 - 5707
  • [6] An overview of the Notch signalling pathway
    Baron, M
    [J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2003, 14 (02) : 113 - 119
  • [7] Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    Berman, DM
    Karhadkar, SS
    Maitra, A
    de Oca, RM
    Gerstenblith, MR
    Briggs, K
    Parker, AR
    Shimada, Y
    Eshleman, JR
    Watkins, DN
    Beachy, PA
    [J]. NATURE, 2003, 425 (6960) : 846 - 851
  • [8] TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    Bhowmick, NA
    Chytil, A
    Plieth, D
    Gorska, AE
    Dumont, N
    Shappell, S
    Washington, MK
    Neilson, EG
    Moses, HL
    [J]. SCIENCE, 2004, 303 (5659) : 848 - 851
  • [9] Tissue architecture: the ultimate regulator of breast epithelial function - Commentary
    Bissell, MJ
    Rizki, A
    Mian, IS
    [J]. CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (06) : 753 - 762
  • [10] Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    Bonnet, D
    Dick, JE
    [J]. NATURE MEDICINE, 1997, 3 (07) : 730 - 737