Use of pentafluorophenyl esters for one-pot protection activation of amino and thiol carboxylic acids

被引：15

作者：

Gayo, LM ^{[1
]}

Suto, MJ ^{[1
]}

机构：

[1] SIGNAL PHARMACEUT INC,DEPT MED CHEM,SAN DIEGO,CA 92121

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 28期

关键词：

D O I：

10.1016/0040-4039(96)00985-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As part of our efforts in the area of combinatorial chemistry, we have been exploring new methods for the construction of combinatorial libraries in a bidirectional fashion. Herein, we describe a new one-pot procedure for the simultaneous protection/activation of amino and thiol carboxylic acids using pentafluorophenyl trifluoroacetate (TFAPfp) and related pentafluorophenyl reagents (FmocPfp and AcPfp). Copyright (C) 1996 Elsevier Science Ltd

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页码：4915 / 4918

页数：4

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