Borreliacidal antibody production against outer surface protein C of Borrelia burgdorferi

被引:44
作者
Rousselle, JC
Callister, SM
Schell, RF
Lovrich, SD
Jobe, DA
Marks, JA
Wieneke, CA
机构
[1] Gundersen Lutheran Med Ctr, Microbiol Res Lab, La Crosse, WI 54601 USA
[2] Gundersen Lutheran Med Ctr, Dept Infect Dis, La Crosse, WI 54601 USA
[3] Univ Wisconsin, Dept Biol & Microbiol, La Crosse, WI 54601 USA
[4] Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA
[5] Univ Wisconsin, Wisconsin State Lab Hyg, Madison, WI 53706 USA
关键词
D O I
10.1086/515382
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Early Lyme borreliosis sera with significant titers of anti-outer surface protein C (OspC) borreliacidal antibodies were identified. Human anti-OspC borreliacidal antibodies could be either IgM or IgG. Significant concentrations of borreliacidal activity were detected after vaccination of mice with OspC, Detection of anti-OspC borreliacidal activity was dependent on surface expression of OspC by Borrelia burgdorferi isolate 50772, The ability of OspC to induce borreliacidal antibodies in vivo and after vaccination offers another possible explanation for the ability of vaccination with OspC to protect against infection with B. burgdorferi, Furthermore, detection of anti-OspC borreliacidal antibodies, especially IgM antibodies, in early Lyme borreliosis sera provides additional evidence that borreliacidal antibody detection may be useful for the serodiagnosis of early Lyme borreliosis.
引用
收藏
页码:733 / 741
页数:9
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