α-Glucosidase inhibitory constituents from stem bark of Terminalia superba (Combretaceae)

被引：66

作者：

Wansi, Jean Duplex

Lallemand, Marie-Christine

Chiozem, David Daco

Toze, Flavien Aristide A.

Mbaze, Luc Meva'a

Naharkhan, Shamsun

Iqbal, Muhammad Choudhary

Tillequin, Francois

Wandji, Jean

Fomum, Zacharias Tanee

机构：

[1] Univ Douala, Fac Sci, Dept Chem, Douala, Cameroon

[2] Univ Yaounde 1, Fac Sci, Dept Organ Chem, Yaounde, Cameroon

[3] Univ Karachi, HEJ Res Inst Chem, Karachi 75270, Pakistan

[4] Univ Paris 05, Fac Sci Pharmaceut & Biol, Lab Pharmacognosie, UMR 8636, F-75006 Paris, France

来源：

PHYTOCHEMISTRY | 2007年 / 68卷 / 15期

关键词：

Terminalia superba; combretaceae; stem bark; lignans; gallic acid; alpha-glucosidase activity;

D O I：

10.1016/j.phytochem.2007.02.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The CH2CI2/CH3OH (1/1) extract of the dried stem bark of Terminalia superba afforded two compounds, (7S,8R,7'R,8'S)-4'hydroxy-4-methoxy-7,7'-epoxylignan and meso-(rel 7S,8R,7'R,8'S)-4,4'-dimethoxy-7,7'-epoxylignan along with 11 known compounds. The structures of the compounds were established by analysing the spectroscopic data and also comparing it with the data of previously known analogues. All the isolated compounds were evaluated for their glycosidase inhibition activities. Gallic acid and methyl gallate showed significant alpha-glucosidase inhibition activity. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2096 / 2100

页数：5

共 16 条

[1]

Antioxidant lignans from Larrea tridentata [J].