Lactation suppresses diurnal rhythm of serum leptin

被引：78

作者：

Pickavance, L

Tadayyon, M

Williams, G

Vernon, RG ^{[1
]}

机构：

[1] Hannah Res Inst, Ayr KA6 5HL, Scotland

[2] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England

[3] Univ Liverpool, Dept Med, Diabet & Endocrinol Res Grp, Liverpool L69 3GA, Merseyside, England

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 248卷 / 01期

关键词：

D O I：

10.1006/bbrc.1998.8934

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rats consume most of their daily food intake at night; serum leptin levels and adipose tissue leptin mRNA content are elevated at night in non-lactating rats fed ad libitum. Lactation induces massive hyperphagia with most food still consumed at night, but the nocturnal increase in leptin secretion was not observed in lactating rats. Thus the link between nocturnal food intake and increased serum leptin is broken during lactation and the hypoleptinaemia may be an important factor promoting the hyperphagia of lactation. (C) 1998 Academic Press.

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页码：196 / 199

页数：4

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