Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration

被引：23

作者：

Chen, Jing ^{[1
]}

Connor, Kip M. ^{[1
]}

Smith, Lois E. H. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp Boston, Dept Ophthalmol, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2007年 / 117卷 / 10期

关键词：

D O I：

10.1172/JCI33513

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Age-related macular degeneration (AMD), the most common cause of blindness in the elderly, is characterized by degeneration of the macula and can lead to loss of fine color vision. Alterations in inflammatory and immune system pathways, which arise from genetic differences, predispose individuals to AMD. Yet the mechanism of disease progression with respect to inflammation is not fully understood. In this issue of the JCI, the study by Combadiere and colleagues shows that CX3C chemokine receptor 1-deficient (CX3CR1-deficient) mice have abnormal microglia that accumulate beneath the retina and contribute to the progression of AMD (see the related article beginning on page 2920).

引用

页码：2758 / 2762

页数：5

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