Synthesis and preliminary pharmacological evaluation of analogues of caracasanamide, a hypotensive natural product

被引：22

作者：

Corelli, F

Dei, D

DelleMonache, G

Botta, B

DeLuca, C

Carmignani, M

Volpe, AR

Botta, M

机构：

[1] UNIV CATTOLICA SACRO CUORE, CTR CHIM RECETTORI, I-00168 ROME, ITALY

[2] UNIV ROMA LA SAPIENZA, DIPARTIMENTO STUDI CHIM & TECNOL SOSTANZE BIOL AT, I-00185 ROME, ITALY

[3] CTR ELETTROCHIM & CHIM FIS INTERFASI, ROME, ITALY

[4] UNIV AQUILA, DEPT BIOL & FISIOL CELLULARE, I-67010 COPPITO, AQ, ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 06期

关键词：

D O I：

10.1016/0960-894X(96)00079-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some analogues of the hypotensive agent caracasanamide have been synthesized and tested in vivo for cardiovascular effects. Derivative 2c emerged as the most interesting compound in the series. Structure-activity relationship is also discussed.

引用

页码：653 / 658

页数：6

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