A potential new therapeutic system for glaucoma: solid lipid nanoparticles containing methazolamide

被引：58

作者：

Li, Rui ^{[1
]}

Jiang, Sunmin ^{[1
]}

Liu, Dongfei ^{[1
]}

Bi, Xinyun ^{[1
]}

Wang, Fengzhen ^{[1
]}

Zhang, Qing ^{[1
]}

Xu, Qunwei ^{[1
]}

机构：

[1] Nanjing Med Univ, Sch Pharm, Nanjing 210029, Peoples R China

来源：

JOURNAL OF MICROENCAPSULATION | 2011年 / 28卷 / 02期

关键词：

DRUG-DELIVERY SYSTEMS; IN-VITRO; ACETAZOLAMIDE; SLN; MICROSPHERES; FORMULATION; RELEASE;

D O I：

10.3109/02652048.2010.539304

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Methazolamide (MTA) is an antiglaucoma drug; however, there are many side effects of its systemic administration with insufficient ocular therapeutic concentrations. The aim of this study was to formulate MTA-loaded solid lipid nanoparticles (SLNs) and evaluate the potential of SLNs as a new therapeutic system for glaucoma. SLNs were prepared by a modified emulsion--solvent evaporation method and their physicochemical characteristics were evaluated. The pharmacodynamics was investigated by determining the percentage decrease in intraocular pressure. The ocular irritation was studied by Draize test. Despite a burst release of SLNs, the pharmacodynamic experiment indicated that MTA--SLNs had higher therapeutic efficacy, later occurrence of maximum action, and more prolonged effect than drug solution and commercial product. Formulation of MTA--SLNs would be a potential delivery carrier for ocular delivery, with the advantages of a more intensive treatment for glaucoma, lower in doses and better patient compliance compared to the conventional eye drops.</.

引用

页码：134 / 141

页数：8

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