Endoplasmic reticulum stress and lipid dysregulation

被引：80

作者：

Colgan, Stephen M.

Hashimi, Ali A.

Austin, Richard C.

机构：

[1] McMaster Univ, Hamilton, ON, Canada

[2] St Josephs Healthcare Hamilton, Dept Med, Hamilton, ON, Canada

[3] St Josephs Healthcare Hamilton, Div Nephrol, Hamilton, ON, Canada

来源：

EXPERT REVIEWS IN MOLECULAR MEDICINE | 2011年 / 13卷

基金：

加拿大健康研究院;

关键词：

STEROL-REGULATORY ELEMENT; CLEAVAGE-ACTIVATING PROTEIN; FATTY-ACID SYNTHESIS; INTRACELLULAR CHOLESTEROL TRANSPORT; LIPOPROTEIN RECEPTOR PROMOTER; LEUCINE ZIPPER PROTEIN; PROGRAMMED CELL-DEATH; RENAL TUBULAR INJURY; BINDING PROTEINS; ER STRESS;

D O I：

10.1017/S1462399410001742

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular cholesterol homeostasis is a fundamental and highly regulated process. Transcription factors known as sterol regulatory element binding proteins (SREBPs) coordinate the expression of many genes involved in the biosynthesis and uptake of cholesterol. Dysregulation of SREBP activation and cellular lipid accumulation has been associated with endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR). This review will provide an overview of ER stress and the UPR as well as cholesterol homeostasis and SREBP regulation, with an emphasis on their interaction and biological relevance.

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页数：14

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