Almond oxynitrilase-catalyzed transformation of substituted aldehydes. Part 2

被引:10
作者
Danieli, B
Frattini, S
Roda, C
Carrea, G
Riva, S
机构
[1] CNR, Ist Chim Ormoni, I-20131 Milan, Italy
[2] Ctr CNR Studio Sostanze Organ Nat, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
关键词
almond oxynitrilase; cyanohydrin; substituted aldehydes; diastereoselectivity;
D O I
10.1016/S1381-1177(98)00039-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Different alpha- and beta-alkyl substituted aldehydes (1-5) have been submitted to the catalytic action of almond oxynitrilase, in order to explore the influence of a stereocenter already present in the substrate molecule on the selectivity of this enzyme. The results indicate that substituents in alpha-position to the aldehyde group significantly influence the stereochemical outcome of the AON-catalyzed transformation, especially when they are of different size. On the other hand, the presence of a beta-substituent seems to have little effect on AON selectivity. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:223 / 228
页数:6
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